IISc’s Light-sensitive Drugs Brighten Anti-cancer Efforts

Published: 17th February 2015 06:03 AM  |   Last Updated: 17th February 2015 06:03 AM   |  A+A-

BENGALURU: A relatively new treatment for cancer could become safer and less expensive, thanks to research at the Indian Institute of Science.

Photodynamic therapy (PDT), using light to treat cancer, is emerging as an alternative to harsh treatments such as chemotherapy or radiation.

In PDT, a drug called a photosensitiser is injected into cancer cells in a non-reactive or dormant form.

When exposed to light of a specific wavelength, the drug gets activated and then triggers the release of a reactive oxygen molecule, which kills the cancer cells.

Researchers at IISc have designed a trio of compounds that can be triggered by light to become toxic to cancer cells.

These target the cells’ mitochondria — their “energy factories” — setting off a chain reaction that turns on cell death pathways and kills the cancer cells.

Better Drugs: The newly-designed compounds could potentially lead to novel mitochondria-targeting cancer drugs that are safe, controlled and efficient.

Prof Akhil R Chakravarty, Department of Inorganic and Physical Chemistry, Babu Balaji, a graduate student, Prof Anjali Karande, Department of Biochemistry, Babita Balakrishnan, a post-doctoral scholar, and Shravanakumar Perumalla, a graduate student, designed the new compounds, a novel blend of organic and metallic components.

Biological studies were carried out with the help of Prof Anjali Karande’s research group.

Chain Reaction: Positively charged elements in the compounds’ structure help them travel across the negatively charged mitochondrial membrane and accumulate inside. When exposed to light, the stable ferrocene in the mix switches to an unstable ferrocenium molecule, triggering the release of reactive oxygen species (ROS). ROS are destructive molecules that start off a chain reaction, eventually killing the cancer cells, a process called apoptosis or programmed cell death.

“Organic (carbon-containing) drugs derived from porphyrin, a cyclic molecule, are currently used in PDT to treat certain lung and esophageal cancers. The new ferrocene-complexes, however, could substitute for these expensive porphyrin-based drugs,” Chakravarty said.

Current Drawbacks: Porphyrin-based drugs are also known to have harmful side effects on the skin, liver and kidney.  

Stay up to date on all the latest Bengaluru news with The New Indian Express App. Download now
(Get the news that matters from New Indian Express on WhatsApp. Click this link and hit 'Click to Subscribe'. Follow the instructions after that.)


Disclaimer : We respect your thoughts and views! But we need to be judicious while moderating your comments. All the comments will be moderated by the newindianexpress.com editorial. Abstain from posting comments that are obscene, defamatory or inflammatory, and do not indulge in personal attacks. Try to avoid outside hyperlinks inside the comment. Help us delete comments that do not follow these guidelines.

The views expressed in comments published on newindianexpress.com are those of the comment writers alone. They do not represent the views or opinions of newindianexpress.com or its staff, nor do they represent the views or opinions of The New Indian Express Group, or any entity of, or affiliated with, The New Indian Express Group. newindianexpress.com reserves the right to take any or all comments down at any time.

flipboard facebook twitter whatsapp