SHIMOGA: City based scholar Sriranjini’s research paper on ‘Design and Development of Potent Vaccine to Tuberculosis by Reverse Vaccinology Approach,’ which was published in the renowned Bio Vaccine Science
Journal, has become a milestone in the field of study on tuberculosis.
Sriranjini, who is pursuing her graduation in BV Bhoomaraddi College of Engineering and Technology at Hubli, told reporters on Monday that people suffering from tuberculosis and her interest in science inspired her to do the research. Despite the advance in science, many people still suffer from tuberculosis and except BCG vaccine, no other effective vaccine has been developed to root out the disease, she added.
She explained that tuberculosis claims many number of people in the world annually, she said it was endemic in most of the countries but resurgent in developed and developing countries where the number of HIV infected people is more. The bacteria causing tuberculosis belongs to a diverse group of micro-organisms known as mycobacterium which are prevalent in human beings, he said.
She said, “My paper aims at developing a vaccine against tuberculosis by reversing the vaccinology approach. Mycobacterium Tuberculosis, the bacteria which causes the disease, will have more than 8,000 proteins. A protein which has less identity and e-value was selected after screening of all proteins. From this, antigen determinants were found, out of which HRRAPL antigenic determinant was found to be good vaccine candidate through docking analysis,” she explained.