After thrashing Melilla in the Copa del Rey, they won 5-0 away to Viktoria Plzen in the Champions League, between victories over Real Valladolid and Celta Vigo in La Liga.
The former Spain coach was appointed in June but five defeats in seven games, the last of them a 5-1 thrashing by Barcelona in El Classico on Sunday, have convinced Madrid to make a change.
Luis Suarez scored a hat-trick to leave Lopetegui's future in serious doubt. After going more than eight hours without a goal earlier this month, Madrid have now managed just one win in six matches.
If Florentino Perez's mind is already made up, the result against Barcelona may not matter. A draw, or even a Madrid win, is not beyond the realm of possibility.
Viktoria Plzen's openings were even clearer and the feeling afterwards at the Santiago Bernabeu was the European champions had been fortunate.
For the rest of the half, Madrid were scatty and imprecise, their finishing spoiled by bad luck but a lack of composure too.
Defeat means Madrid have now gone five games without a victory and by the time Marcelo gave them hope of a comeback at the Santiago Bernabeu, they had gone 481 minutes without a goal too.
Madrid have gone three games without scoring, after their surprise Champions League loss to CSKA Moscow on Tuesday followed a draw against Atletico Madrid and defeat to Sevilla.
Madrid, who have won the past three Champions League titles, started this campaign with a 3-0 win over Roma.
Bale picked up a thigh injury during the goalless draw with Atletico Madrid on Saturday and had to come off at half-time.
Lopetegui declined to take credit for the improvement of Benzema's play, stating that the players are the ones who play and overcome the difficulties.
Lopetegui stressed that the Portuguese's departure represented a "fantastic opportunity" for Bale, who has been linked by Spanish media with a move away from the club, to stay and show his talent.
Cristiano Ronaldo's hat-trick denied Spain the perfect response to a turbulent week following the sacking of Julen Lopetegui in a thrilling 3-3 draw in Sochi.
Lopetegui has given his backing to Spain at the World Cup, despite being fired as coach just 48 hours before their opening game at the tournament in Russia.
Cristiano Ronaldo's focus is on his fourth and probably last chance to win a World Cup at the peak of his powers.