Priyanka Chopra said it was an emotional moment for her to see the couple exchange their wedding vows at the Windsor Castle.
Celebrities from Britain and North America took their places among the 600 guests the chapel, including US former actress Markle's co-stars in the TV legal drama series "Suits".
The overall message at the Hollywood Foreign Press Association's champagne-drenched annual prize-giving was a call for continued change.
With all the eloquent speeches, none roused the room like Winfrey's, who had the crowd giving her repeated ovations not once, but three times.
Winfrey became the first black woman to be given the Cecil B. DeMille Award.
Actress Jennifer Lawrence says Hollywood producer Harvey Weinstein, who has been accused of rape and sexual harassment, was paternal towards her and that she never knew he was a rapist.
Winfrey, who previously has publicly discussed the story of her sexual harassment, believes the more women speak out, the less fear they’ll have over breaking their silence.