- Tag results for Sai Praneeth
Commonwealth Games bronze medallist pair of Ashwini Ponnappa and N Sikki Reddy also bowed out of the competition, losing 14-21 14-21 to Thailand's Jongkolphan Kititharakul and Rawinda Prajongjai
Former Olympic bronze medallist, Saina will next face eight-seeded compatriot Rituparna Das, who beat fellow Indian Shruti Mundada 21-11 21-15 in a one-sided clash.
Sindhu has been outstanding this season with silver medals in all the major events this year -- the Commonwealth Games, the World Championship and the Asian Games.
It was the first major test for the Taiwanese world number 7 Chen but he downed 38-year-old Lee in just 31 minutes.
Sixth seed Praneeth, who has been out of form of late, went down 21-16 16-21 18-21 to Igarashi in a match that lasted an hour and 11 minutes.
India have been clubbed with Australia, France and heavyweights China in Group A.
B Sai Praneeth, who was the lone Indian left in fray in the tournament, finally lost to Jonatan Christie of Indonesia in the Men's Singles semi-finals on Saturday.
The Indians had a field day during the opening round of the tournament with the likes of B Sai Praneeth, Ajay Jayaram and Sameer Verma also recording victories in their respective matches.
With Srikanth ranked three in the world, HS Prannoy 11th and Sai Praneeth 14th, India have as many men in the world top 15 as traditional powerhouse China.
Praneeth lost to top-seeded Viktor Axelsen of Denmark 17 -21, 8-21 while Ponnappa and Sikki Reddy went down to Denmark's Kamilla Rytter Juhl and Christinna Pedersen 15-21, 15-21.
Praneeth got the better of Thailand's Kantaphon Wangcharoen 21-13, 21-13 in 44 minutes in the first round.
Fourth seed PV Sindhu moved past South Korean world No.44 Kim Hyo Min 21-16, 21-14 in 49 minutes.