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The 51-year-old, who has struggled with alcoholism since he retired from top-flight football, was arrested at Durham station in northeast England on August 20.
It gave Tottenham a glimmer of hope of a top-two finish in Group B with matches still to come at home to Inter Milan and away to already-qualified Barcelona.
It has been suggested the former Southampton and Espanyol boss, yet to win a trophy in four and a half seasons with the north London club, has taken Tottenham as far as he can without major investment
Dele Alli joined Tottenham in 2015 and has scored 48 goals in 153 competitive appearances for the club.
Playing on the scarred Wembley turf just 24 hours after it was damaged by an NFL fixture, City's peerless quality and a predatory finish from Mahrez helped them ignore the pitch problems.
A throwaway comment by Guardiola last year seemed to cause Pochettino offence with what he saw as the suggestion that Spurs are a “one-man” team.
The Argentine winger was preferred to fit-again playmaker Christian Eriksen by manager Mauricio Pochettino
Messi, who had earlier twice hit the post, then got on the scoresheet in between goals from Harry Kane and Erik Lamela, before the Argentina superstar grabbed his second late on to seal victory.
Pochettino will draw on the memory of the most cherished success of his career when Tottenham host Barcelona.
Barcelona is set to work out at Wembley on Tuesday, after which Valverde and Ivan Rakitic are to hold a press conference.
An abdominal problem means Christian Eriksen will not travel to Yorkshire, giving Lamela a potential chance to start at the John Smith's Stadium.
Harry Kane converted a first-half penalty in typically cool fashion to take him level with Jermain Defoe on 143 goals for the club.
Harry Kane ended a five-game goal drought from the penalty spot and Erik Lamela doubled Tottenham's lead before Anthony Knockaert pulled a late goal back for Brighton.
Spurs moved back up to fifth in the Premier League, still six points adrift of leaders Liverpool.
Hugo Lloris' stress over drink-driving could have contributed to injury: Tottenham manager Mauricio Pochettino
Spurs have suffered three consecutive defeats since the Frenchman was injured -- back-to-back Premier League losses and a Champions League reverse at Inter Milan.