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The United manager left Pogba out of his starting line-up for the second time this week as his side recorded their biggest victory in 13 months, 4-1 over last-placed Fulham.
Mourinho's comments appear to be aimed at Manchester City, who are the subject of an ongoing investigation by European football's governing body into alleged FFP breaches.
Jose Mourinho's team is now six points off the Champions League qualifying places and a massive 16 behind first-place Manchester City.
De Gea joined Manchester United in 2011 and has won the fans' player of the year award in four of the past five seasons.
The 29-year-old Chilean forward, dropped from the squad for Tuesday's 1-0 Champions League win over Swiss outfit Young Boys, suffered the injury in training on Thursday.
Win the Manchester derby on Sunday and City will already be 12 points clear of United just 12 games into the new season, a gap that has gradually widened in each of the past three years.
Mourinho's Manchester United side travel across the city on Sunday for a Premier League derby against their neighbours, who are two points clear at the top of the table.
Mourinho responded in typically controversial fashion as the United manager marched onto the pitch at the final whistle with his hand cupped to one ear.
Mourinho acknowledged United could have been three or four goals behind by half-time at Dean Court on Saturday.
Juventus will look to keep their unbeaten streak in Serie A against the Sardinians in Turin four days before taking on Jose Mourinho's United in the Allianz Stadium.