A Scientific Discovery
Joint efforts of Dr Hridayesh Prakash, Ph. D (Ramanujan Fellow), Department of Biochemistry, School of Life Sciences, University of Hyderabad (UoH) together with members of his previous institute led to an important discovery which was made at German Cancer Research Center in Germany.
Their pioneer work shows the indispensable role of macrophages, one of the major components of innate immune system, in affording immunity against neuroendocrine, solid and non-resectable tumor of pancreas. Their experiments explicitly demonstrated that replenishment of resident macrophages by gamma rays programmed macrophages in a therapeutic setting in tumor bearing mice potentially inhibited the tumor supply of nutrients (angiogenesis), facilitated migration of effector T cell into tumor tissue and caused a successful tumor rejection.
These observations were dependent on iNOS enzyme which is expressed by tumor regulatory macrophages. Taken together their work revealed the significance of macrophages directed approaches as indispensable components of future immunotherapeutic strategies against established tumors.
This study has been published in the recent issue of very high impact journal known as *Cancer cell *with an* impact factor of 27.5 .* Dr. Prakash is an M.Sc from IIT Roorkee and a PhD from Jamia Millia Islamia, New Delhi and Institute of Nuclear Medicine and Allied Science, DRDO. His field of specialization includes Pulmonary Infection Biology, Macrophages Immunobiology, Host Apoptosis regulation, Signal Transduction, Tumour Immunology (lung and pancreatic cancer).
He has worked as Post Doctoral Scientist at the Department of Dermatology, University Medical Centre, Heidelberg, Germany; Post Doctoral Scientist at the Translational Immunology Group, National Centre for Tumor Diseases, German Cancer Research Centre, Heidelberg Germany; Postdoctoral fellow at the Cell Biology and Biophysics Division, European Molecular Biology Laboratory, Heidelberg and as Postdoctoral fellow in the Department of Molecular Biology, Max-Planck Institute for infection Biology, Berlin before joining University of Hyderabad.
Presently, he is working at UoH as Department of Science and Technology Ramanujan Fellow.