STOCK MARKET BSE NSE

New Treatment Brings Hope for Malaria Patients

Published: 23rd December 2013 03:10 PM  |   Last Updated: 23rd December 2013 03:10 PM   |  A+A-

By IANS

In view of increasing cases of malaria treatment failures reported across the globe, scientists have now identified a way to stop malaria parasites from multiplying, raising hope for a new malaria treatment.

A team of scientists led by Ed Tate, of the Department of Chemistry at Imperial College, London, have shown that blocking the activity of an enzyme called NMT in plasmodium falciparum, the most common malaria parasite, prevents mice from showing malaria symptoms and also extends their lifespan.

NMT is involved in a wide range of essential processes in the parasite cell, including the production of proteins that enable malaria to be transmitted between humans and mosquitoes, and proteins that enable malaria to cause long-term infection, said the study.

“Finding an enzyme that can be targeted effectively in malaria can be a big challenge. Here, we’ve shown not only why NMT is essential for a wide range of important processes in the parasite, but also that we can design molecules that stop it from working during infection,” Tate said.

“It has so many functions that we think blocking it could be effective at preventing long-term disease and transmission, in addition to treating acute malaria,” he added.
The scientists expect the treatment to work not just on plasmodium falciparum but on other malaria parasites as well.

However, although the researchers have tested a handful of molecules that block the activity of NMT in the parasite living inside human red blood cells, and in mice, the treatment is not yet refined enough to be tested in humans.

"We need to do some more work in the lab to find the best candidate molecule to take into clinical trials, but hopefully we'll be ready to do that within a few years," Tate said.

The findings of the study appeared in the latest edition of the journal Nature Chemistry.



Comments

Disclaimer : We respect your thoughts and views! But we need to be judicious while moderating your comments. All the comments will be moderated by the newindianexpress.com editorial. Abstain from posting comments that are obscene, defamatory or inflammatory, and do not indulge in personal attacks. Try to avoid outside hyperlinks inside the comment. Help us delete comments that do not follow these guidelines.

The views expressed in comments published on newindianexpress.com are those of the comment writers alone. They do not represent the views or opinions of newindianexpress.com or its staff, nor do they represent the views or opinions of The New Indian Express Group, or any entity of, or affiliated with, The New Indian Express Group. newindianexpress.com reserves the right to take any or all comments down at any time.

IPL_2020
flipboard facebook twitter whatsapp