NEW DELHI: More than 47 per cent of antibiotic formulations used in India's private sector in 2019 were not approved by the central drug regulator, according to a study published in The Lancet Regional Health-Southeast Asia.
The study was conducted by Shaffi Fazaludeen Koya, Veronika J. Wirtz, Sandro Galea and Peter C. Rockers from Department of Epidemiology, Boston University School of Public Health, along with Senthil Ganesh and Sakthivel Selvaraj from the Public Health Foundation of India, New Delhi.
The research also found that azithromycin 500mg tablet was the most consumed antibiotic formulation (7.6 per cent) in India, followed by cefixime 200 mg tablet (6.5 per cent) during the year.
Inappropriate use of antibiotics is a significant driver of antibiotic resistance in India, the authors of the study noted in the journal.
"Largely unrestricted over-the-counter sales of most antibiotics, manufacturing and marketing of many FDC and overlap in regulatory powers between national and state-level agencies complicate antibiotics availability, sales, and consumption in the country," they said.
The team analysed cross-sectional data from PharmaTrac, a nationally representative private-sector drug sales dataset gathered from a panel of 9000 stockists across India who store products from approximately 5,000 pharmaceutical companies. However, these data did not include the drugs dispensed through public facilities.
The researchers examined the private sector antibiotic use, which contributes to 8590 per cent of the total consumption in India.
The researchers found a lower consumption rate of antibiotics compared to previous estimates but very high relative consumption of broad-spectrum antibiotics, which act against a wide range of disease-causing bacteria.
The total defined daily dose --- the assumed average maintenance dose per day for a drug in adults --- consumed in 2019 was 5,071 million (10.4 DDD/1,000/day), they said.
"To reach this conclusion, we used the AWaRe (Access, Watch, Reserve) classification and the defined daily dose (DDD) metrics to calculate the per capita private-sector consumption of systemic antibiotics across different categories: FDCs vs single formulations; approved vs unapproved; and listed vs not listed in the national list of essential medicines (NLEM)," the team said.
The study shows that formulations listed in the national list of essential medicines (NLEM) contributed 49 per cent while fixed-dose combinations (FDC) contributed 34 per cent, and unapproved formulations were 47.1 per cent.
FDCs are the combinations of two or more active drugs in a single dosage form.
"Centrally unapproved formulations accounted for 47.1 per cent (2,408 million) of total DDDs," the authors of the study noted.
"Cephalosporins, macrolides, and penicillins were the top three antibiotic classes among unapproved formulations," they said. The Watch group of antibiotics constituted 72.7 per cent of unapproved products and combinations discouraged by the World Health Organization (WHO) constituted 48.7 per cent of FDCs.
Watch includes broad-spectrum antibiotics with a high chance of resistance to be used only for specific indications.
'India does not have a formal system to monitor antibiotic use'
"We do not have proper surveillance systems monitoring antibiotic usage in our country and irrational antibiotic usage is rampant," said Dr. Hari Kishan Boorugu, Consultant Physician & Diabetologist, Yashoda Hospitals Hyderabad.
"Problem lies at multiple levels -- antibiotic usage by patients without prescription, irrational usage of antibiotics by quacks and even by many qualified doctors," Boorugu told PTI.
The study provides evidence for policymakers to strengthen the existing policy measures and institute new efforts to achieve the global targets of appropriate use of antibiotics, the researchers said.
Restricting the sale of unapproved formulations, expanding the national essential medicines list to include more antibiotics, strengthening antibiotic stewardship programs in private sector, expanding access to appropriate antibiotics through public health system, and tightening the legal regulation of over-the counter sales of antibiotics may help to address inappropriate use of antibiotics, the study emphasised.
The authors acknowledge some limitations to their study, including the fact that the dataset covers only the private sector sales of antibiotics and will not reflect the antibiotics dispensed through the public system.
Also, the data do not differentiate between community and hospital use as the data are collected at the stockist level, they said.
"Prevalence of multidrug resistant bacterial infection is high in many countries including India and irrational usage of antibiotics is a major driving factor for this menace," Booruge explained.
"Unless we act now, soon we will be in a situation like pre-antibiotic era without effective antibiotics for treating most bacterial infections," he added.
(With inputs from PTI and IANS)