Test detects drug-resistant TB bacteria

Other TB tests face issues in sensitivity to detect mutation, take long or detect resistance to some drugs only.

Published: 09th August 2019 06:21 AM  |   Last Updated: 09th August 2019 06:21 AM   |  A+A-

By Express News Service

BENGALURU: MedGenome Labs, a city-based genetic testing lab, has developed ‘SPIT SEQ’, the first-of-its-kind Whole Genome Sequencing-based test, that can detect drug-resistant tuberculosis (TB) bacteria. A hundred samples were tested in collaboration with multiple hospitals and the proprietary discovery will help for quicker diagnosis and treatment, which is an issue that other TB tests face currently. The test was commercially launched on Thursday and is expected to bring down mortality rates.  
Other TB tests face issues in sensitivity to detect mutation, take long or detect resistance to some drugs only. For example,  MTB test (Mycobacterium tuberculosis) is slow-growing, taking 6-8 weeks for culture growth, thereby delaying not only TB diagnosis but also the drug resistance testing. SPIT SEQ is a culture-free WGS (whole genome sequencing) method. Culture tests involve studying bacteria by growing the bacteria on a different substance.

“ We are supplementing these tests with SPIT SEQ than includes taking sputum sample (mix of saliva and mucus), take DNA of the bacteria and perform genome sequencing. A single test can diagnose TB and detect mutation present in any tuberculosis bacteria causing drug resistance. The turn around of the test is 10 days,” said Dr VL Ramprasad, Chief Operating Officer, MedGenome Labs. Of the 100 samples, 48 were from P D Hinduja Hospital and Medical Research Centre, Mumbai.

“Poor accuracy of detecting TB makes diagnosis slow. All 48 samples we received tested positive,” said Dr Camilla Rodriques, consultant microbiology and chairperson of Infection Control Committee at Hinduja.

The test costs between Rs 8000 and Rs 10,000.

Stay up to date on all the latest Karnataka news with The New Indian Express App. Download now
(Get the news that matters from New Indian Express on WhatsApp. Click this link and hit 'Click to Subscribe'. Follow the instructions after that.)

Comments

Disclaimer : We respect your thoughts and views! But we need to be judicious while moderating your comments. All the comments will be moderated by the newindianexpress.com editorial. Abstain from posting comments that are obscene, defamatory or inflammatory, and do not indulge in personal attacks. Try to avoid outside hyperlinks inside the comment. Help us delete comments that do not follow these guidelines.

The views expressed in comments published on newindianexpress.com are those of the comment writers alone. They do not represent the views or opinions of newindianexpress.com or its staff, nor do they represent the views or opinions of The New Indian Express Group, or any entity of, or affiliated with, The New Indian Express Group. newindianexpress.com reserves the right to take any or all comments down at any time.

flipboard facebook twitter whatsapp