Aaron Ramsey was forced off in the 59th minute of Juventus' 2-2 draw at Udinese in its Serie A opener on Sunday.
Roberto Mancini's side play Wales for top spot in Group A in Rome, after 3-0 wins over both Turkey and Switzerland put them through to the last 16.
The Juventus playmaker has scored goals in crucial qualifying matches, claimed three assists at Euro 2016 and starred in three FA Cup final wins for former club Arsenal.
Gareth Bale was the subject of incessant transfer reports as his initially succesful time at Madrid became plagued by injuries.
The Swiss would certainly like to start with a win over Wales ahead of what may be tougher Group A games against Italy and a resurgent Turkey team that will have passionate support in Baku.
Substitutes Aaron Ramsey and Olivier Giroud scored as Arsenal twice came from behind to beat Leicester City 4-3.