In other women's action Sunday, No. 3 Jessica Pegula got to the quarterfinals in Australia for the third year in a row by defeating 2021 French Open champion Barbora Krejcikova 7-5, 6-2
Given that Mirza, a six-time Major champion, will retire after the Dubai Open next month, this was her final appearance in a women's doubles Grand Slam match.
Ostapenko edged a tight battle 7-5, 6-3 in an 1hr 33min on Margaret Court Arena to reach the quarter-finals at Melbourne Park for the first time.
Rybakina's victory means the top two seeds in both the men's and women's singles are all out of the first Grand Slam of the year before the last-eight stage.
Victory put Djokovic into the last 16 for a 15th time but he was made to work for it, especially with his left hamstring troubling him.
The 35-year-old Murray was clearly feeling the effects of his epic five-setter in round two, which started on Thursday but ended in the early hours of Friday.
Pegula was wearing a white screen-printed patch with Hamlin’s uniform number on her black skirt while she competed at the Australian Open, AP reported on January 18.
"I feel like I have to stay really aggressive in the first few shots and then the slower ball or shorter ball will come," Sabalenka told reporters at Melbourne Park.
Danish teenager Rune beat Ugo Humbert 6-4, 6-2, 7-6 (5) to move into the fourth round on just his second visit to Melbourne Park.
Medvedev was a losing finalist at the last two Australian Opens, to Novak Djokovic in 2021 and then in a demoralising five-set defeat 12 months ago against Rafael Nadal after leading by two sets.
Jabeur had complained of a knee problem after her opening victory at Melbourne Park and seemed out of sorts for much of the loss against Vondrousova, which ended a little past 1 am on Friday.
Taylor Fritz and Alexander Zverev also became high-profile casualties.
Sania and her Kazakh partner Anna Danilina prevailed over Hungary's Dalma Galfi and American Bernarda Pera 6-2 7-5 in one hour and 15 minutes in the women's doubles.
He considered quitting but played on because he was the reigning champion. Nadal also was seeded No.1 at Melbourne Park, because top-ranked Carlos Alcaraz is out with a leg injury.
Nadal was the defending champion and seeded No.1 in Australia. The 36-year-old now will head home to Spain to rest.
Currently ranked 77th, Raducanu has been dealing with an ankle injury. Yet she was so close to extending this match, holding a pair of set points while ahead 5-4 in the second set.
"It's a tough moment. It's a tough day," said Nadal, a 35-year-old Spaniard. "I can't say that I am not destroyed mentally at this moment, because I would be lying."
The reigning French Open and U.S. Open champion will now play either Bianca Andreescu of Canada.
Shri Shiva Vishnu Temple in Carrum Downs, Victoria, was vandalised on Monday, while the Swaminarayan temple in Melbourne was defaced with anti-India graffiti on Jan 12.
The 35-year-old, who was banned from last year's tournament, showed few signs of the hamstring niggle he picked up in Adelaide this month as he raced to victory on Rod Laver Arena 6-3, 6-4, 6-0.