Benoit Paire tasted his first win over a top-ten player since 2017 when he defeated fifth seed Denis Shapovalov.
Paire went down to a 6-3, 6-4, 6-0 loss to Diego Schwartzman in a match carried over from Monday with the Argentine two sets up.
After beating Benoit Paire, the often-injured Andy Murray, who has undergone two hip surgeries, had to pause to gain his composure before speaking.
Fifth seed Juan Martin del Potro overcame service troubles to beat Benoit Paire on Court Two and reach the Wimbledon fourth round.
The former world number one, who was crowned Wimbledon champion in 2013 and 2016, is making slow progress in his return from hip surgery in January.
Wimbledon starts on Monday and Murray, who hasn't publicly announced he is fit enough to play, is due to face the media in a press conference on Saturday.