Xavi Hernández is set to make his coaching debut at his boyhood club FC Barcelona when it hosts Espanyol in a derby at Camp Nou.
Xavi takes over a team that under Ronald Koeman and caretaker coach Sergi Barjuan only managed to win four of 12 league games this season while losing to Real Madrid and Atlético Madrid.
Griezmann was replaced in the 58th by João Felix, who hadn't played this season because of an injury.
Their 1-0 victory at the Santiago Bernabeu may only give Madrid 24 hours above Barcelona, who play Girona on Sunday, with their perfect record still intact.
Lionel Messi scored a hat trick to lead its 5-0 win over crosstown rival Espanyol on Saturday, making it the only side so far to win its first three games in La Liga.
The 20-year-old France striker, signed by Barcelona to replace Neymar is expected to make his debut in the Catalan derby against Espanyol this weekend.