Varane, who has suffered several long-term injury absences during his career, adds to France coach Didier Deschamps' headaches ahead of his naming his squad for the finals in Qatar on November 9.
At 41 years and 56 days, Joaquín becomes the oldest goalscorer in the competition history.
Rangers ended a tumultuous week by winning the Scottish Cup after beating Hearts 2-0 after extra time in the final on Saturday.
Rangers face Eintracht Frankfurt in Seville aiming to add to their 1971/72 Cup Winners' Cup success.
A victory would earn the club its first cup on the continent since Rangers beat Dynamo Moscow 3-2 in Barcelona to lift the Cup Winners' Cup in 1972.
Giorgio Chiellini said he would think about whether to hang up his boots after having already decided to retire from international football.
Eintracht Frankfurt and Rangers will get a chance to end decades of despair when they meet in the Europa League final on Wednesday.
German newspaper Bild said that fans seated behind the commentators punched them and pulled a headset off one of them during Thursday night's first leg, which Frankfurt won 2-1
Both clubs are bidding in what would be their biggest match in decades. Frankfurt's last final came when it won the UEFA Cup in 1980. West Ham's last game was the 1976 Cup Winner's final.
Barcelona have won just once at home in Europe this season, edging Dynamo Kiev 1-0 during their failed Champions League group-stage campaign.
Sevilla have the incentive of trying to reach a final that will be played in their own stadium, the Ramon Sanchez Pizjuan, on May 18.
Simeone has worked wonders with Atletico Madrid since being appointed in late 2011 and winning the Europa League just six months later.
Koke could play off the front two of Griezmann and Diego Costa, offering the same kind of threat that saw him score the winner at Getafe in La Liga at the weekend.
Five minutes after coming on as a substitute, Rolando volleyed in a corner from captain Dimitri Payet in the 116th minute.
Juventus will have a much busier schedule in the run into the title as they fight for silverware on three fronts.
Borussia Dortmund meanwhile face potentially the weakest team in the last 16, Czech side Plzen.
Arsenal moved into Friday's last-16 draw, but Ostersunds will take all the plaudits for a brave display full of quality.
A Basque police officer died Thursday as security forces clashed with fans of Russian club Spartak Moscow.
Timo Werner scored a brace as RB Leipzig took a big step towards the Europa League last-16 on Thursday with a 3-1 comeback win at Serie A leaders Napoli.
Everton, who spent heavily in the close-season, were eliminated from the Europa League after Thursday's defeat to Atlanta.