The 26-year-old Sindhu had made it to the last four in Indonesia Masters last week and also at the French Open in October.
Third seed Sindhu, the reigning world champion, had to toil hard to get the better of Yujin 14-21 21-19 21-14 in the quarterfinal that lasted an hour and six minutes.
Indonesia has reported more than 4.25 million cases and 143,000 deaths from COVID-19 among its 270 million people.
After a slow start, Sindhu, the reigning world champion, engineered a turnaround to register a hard-fought 17-21 21-17 21-17 win over Japan's Ohori in one hour 10 minutes to advance to the pre-qfs.
The men's doubles pair of MR Arjun and Dhruv Kapila also suffered a loss and as a result, the duo bowed out of the tournament.
Just days after their semifinal finishes at Indonesia Masters Super 750, the two top Indian shuttlers will begin their campaign at the World Tour Super 1000 event in their quest for title.
India's challenge in the event now rests on Kidambi Srikanth, who will play third seed Anders Antonsen of Denmark in the men's singles semifinals, later in the day.
Playing on Court 2, former world number one Kidambi beat the 2014 Indonesia Masters champion Prannoy by 21-7, 21-18 in a 39-minute encounter.
Reigning world champion Sindhu, seeded third, scripted a convincing 21-13 21-10 win over the unseeded Yigit in 35 minutes to extend her dominating head-to-head record against the Turkish shuttler.
Prannoy beat Tokyo Olympics gold-medallist Victor Axelsen 14-21 21-19 21-16 in a tense one hour 11 minutes battle in the men's singles second round.
The two-time Olympic medallist will now lock horns with world no 30 unseeded Turkish shuttler Neslihan Yigit in the quarterfinals.
The arrangement with Indonesia is only one way, letting visitors from that country into Singapore without quarantine while locking travellers from the city-state out.
Among others, sixth seeded Indian men's doubles pair of Satwiksairaj Rankireddy and Chirag Shetty will be up against Malaysia's Ong Yew Sin and Teo Ee Yi later in the day.
Agus Arianto that an autopsy was underway by a team of vets to determine the causes of the baby elephant's death.
Indonesia Masters: PV Sindhu eyes podium finish; Saina Nehwal, Sameer Verma pull out due to injuries
Sindhu, who had claimed a bronze at the Tokyo Olympics to go with her Rio silver medal, reached the quarterfinals and semifinals at Denmark and France before skipping the Hylo Open in Germany.