A tough quarterfinal awaits fourth-seeded Sindhu as she will take on the winner of the match between Thailand's fifth seed Ratchanok Intanon and Kirsty Gilmour of Scotland.
The 20-year-old from Almora, who was part of the Indian team that claimed a historic Thomas Cup title triumph in Bangkok, prevailed 21-18 21-15 over world number 13 Gemke in 54 minutes.
India's challenge in the event now rests on Kidambi Srikanth, who will play third seed Anders Antonsen of Denmark in the men's singles semifinals, later in the day.
Playing on Court 2, former world number one Kidambi beat the 2014 Indonesia Masters champion Prannoy by 21-7, 21-18 in a 39-minute encounter.
Reigning world champion Sindhu, seeded third, scripted a convincing 21-13 21-10 win over the unseeded Yigit in 35 minutes to extend her dominating head-to-head record against the Turkish shuttler.
Prannoy beat Tokyo Olympics gold-medallist Victor Axelsen 14-21 21-19 21-16 in a tense one hour 11 minutes battle in the men's singles second round.
The two-time Olympic medallist will now lock horns with world no 30 unseeded Turkish shuttler Neslihan Yigit in the quarterfinals.
Among others, sixth seeded Indian men's doubles pair of Satwiksairaj Rankireddy and Chirag Shetty will be up against Malaysia's Ong Yew Sin and Teo Ee Yi later in the day.
Indonesia Masters: PV Sindhu eyes podium finish; Saina Nehwal, Sameer Verma pull out due to injuries
Sindhu, who had claimed a bronze at the Tokyo Olympics to go with her Rio silver medal, reached the quarterfinals and semifinals at Denmark and France before skipping the Hylo Open in Germany.