Anand ended the tournament in ninth position behind GM Peter Leko who finished last.
Going into the match against the Chinese after ending his six-match losing streak, Anand surrendered the first game in just 22 moves late on Tuesday.
Anand's struggles continued in the USD 150,000 Legends of Chess online tournament as he suffered his sixth consecutive defeat with a 2-3 loss to Nepomniachtchi of Russia.
The former world champion got off to a good start and won the first game of the best-of-four contest but went down 2-3 to Peter Leko of Hungary.
The former world champion Indian and Giri played out four draws before the Dutch player pulled off a win in the Armageddon game (a tie-break) late on Friday.
Viswanathan Anand and Ding Liren lie at the bottom of the points table, without a win against their name.
Viswanathan Anand went down 1.5-2.5 to Russia's Peter Svidler in the opening round of the Legends of Chess tournament.
The round-robin games, beginning from Tuesday, are best-of-four game contests to be played online.