Ake is City's second signing of the delayed summer transfer window, after the club landed Spain Under-21s winger Ferran Torres from Valencia.
City is looking to win the Champions League for the first time but the side must first get past Madrid, the 13-time Champions League winners.
With his stint with Manchester City, Silva managed to win four Premier League titles, two FA Cups and five EFL Cups.
The 32-year-old Aguero is currently going through his recovery week and Guardiola has said that he would have a full squad for the match against Madrid.
UEFA punished Man City in February for "serious breaches" of rules monitoring club finances and failing to cooperate with investigators.
Having missed out on the Premier League, Manchester City would now be hoping to win the FA Cup and Champions League.
All games are being held behind closed doors to curb the spread of the deadly virus which has taken the world by storm.
The match also saw a controversial moment when a message saying 'White Lives Matter Burnley' was flown over the Etihad Stadium.
Manchester City made a scintillating restart to their 2019-2020 campaign as the club secured a sumptuous 3-0 win over Arsenal here on Thursday.
Coronavirus outbreak: Manchester City striker Sergio Aguero teaching British kids to count in Spanish
Aguero says it's a tough time for children at the moment, and also for parents trying to keep them focused on their education from home.
Ilkay Gundogan believes that Wolves striker Raul Jimenez has the potential to play for Manchester City.
Leroy Sane is viewed as one of Germany's brightest talents and has scored five goals in 21 appearances for his country.
Manchester City says everyone associated with the club sends their most heartfelt sympathy at this most distressing time to Pep Guardiola.
There has been considerable criticism from former players, who believe the safety net is not being used as intended. Liverpool announced a EUR 42 million (USD 51 million) pre-tax profit in February.
Guardiola made eight changes from the side that won 2-1 at Real Madrid in the Champions League on Wednesday with Kevin De Bruyne among those left on the bench.