Juventus have sacked Maurizio Sarri following their Champions League exit at the hands of Lyon.
The Portugal forward has not missed a match since the return of Italian football from the coronavirus hiatus.
Cagliari's 20-year-old forward Luca Gagliano tapped in the opener eight minutes into his first Serie A match, beating veteran Juventus keeper Gianluigi Buffon to score his first top division goal.
Juventus have only won one game in their last five fixtures. The Bianconeri will claim a ninth straight Scudetto title if they beat Sampdoria.
Sarri does not want Juventus to dwell on the defeat suffered against AC Milan as he stressed that his side 'must remain calm'.
Ronaldo failed to find the back of the net in back-to-back matches and Sarri stated he didn't say anything to the players after the game as he was disappointed just like them.
The visitors will also be able to call on a Cristiano Ronaldo in splendid form, with the Portuguese star has scored 19 goals since the start of December.
Juventus secured a 2-0 win against Bayern Leverkusen on Thursday in Champions League with Ronaldo scoring the opening goal. Both the goals were scored in the second half of the game.
Mourinho had to be restrained by stewards when one of Chelsea boss Maurizio Sarri's backroom staff ran in front of the Portuguese to celebrate as the hosts salvaged their unbeaten start
Conte leaves with the best win percentage 65.1% of any of Chelsea's managers in the Premier League era.
Sarri won plaudits for the expansive passing football his Napoli team played in the three seasons he was in charge, but he failed to halt Juventus' dominance of Serie A.
The polish on Conte's tenure at Chelsea has become tarnished both at boardroom level and amongst his players.
The 59-year-old former banker has been linked with Chelsea to replace fellow Italian Antonio Conte whose future at the English Premier League club remains uncertain.
Juventus will have a much busier schedule in the run into the title as they fight for silverware on three fronts.
Napoli coach Maurizio Sarri expressed his gratitude to RB Leipzig bosses for building a room where he can puff away.