When these two teams met in the reverse fixture back in November, it was Hyderabad who emerged victorious thanks to an Aridane winner.
A first victory from the last five attempts meant last year's runners-up rise to fifth in the table with 14 points from 11 games.
Points are crucial for both sides as the two teams are languishing in the bottom four. Odisha are dead last with only six points from 10 games, Chennaiyin are eighth with 11 points from 10 games.
The sixth instance of a goalless contest in this edition of the ISL means Chennaiyin are still eighth with 11 points from 10 games while Odisha climbed a spot to tenth with six points from 10 games.
Chennaiyin let in four goals against Hyderabad, the same number they conceded in their first four matches. Add to it their misfiring attack which has scored only eight goals, the lowest in the league.
Kerala forwards Jordan Murray and Gary Hooper were on target for Kibu Vicuna's side but that was not enough as they were thoroughly outplayed.
The result meant Odisha remain rooted to the bottom of the table with two points from eight games.
East Bengal rode on first-half goals from Anthony Pilkington and Jacques Maghoma and a late Bright Enobakhare strike to secure their first victory of this campaign.
Odisha are rock bottom with two points from seven games while the Kolkata giants have a point more from the same number of games.
The result means Odisha gain only their second point of the campaign from seven games and climb a spot to 10th.
The numbers for Odisha don't make for good reading. They have just one point from five outings and have scored the least number of goals in the league so far.
Touted as one of the favourites for the ISL title this season, Mumbai City FC justified that billing with an impressive 2-0 win over Odisha FC.
Mumbai had built a good squad under the former FC Goa coach Sergio Lobera, who is known for his attractive brand of football.
While other sides organized practice matches against each other and are still doing that in between the ISL fixtures, ATK Mohun Bagan have stuck to their regimen and training sessions.