Having moved to the top of the group with victories over AC Milan and Porto, the six-time European Cup winners head to Madrid to face the Spanish champions.
Of Mane’s century of goals for the Reds, which have come in 224 games, 10 have been scored against Palace.
Since the last time there was a full house at Anfield, in March 2020, Liverpool has won the league title for the first time in 30 years and relinquished it to Manchester City.
While Sadio Mane refused to shake hands with the manager, Jurgen Klopp said there wasn't much to read into the episode.
Mane who has scored more than 20 goals in each of the last three seasons, has managed to score just 14 times in the ongoing campaign.
The Senegal international scored 10 goals as Liverpool reached last season's Champions League final, and has started the new campaign strongly, netting six times in 11 Premier League games.
Mane, who left a rural village in southern Senegal as a teenager to find international stardom in Europe, hopes to defy the odds again at the World Cup in Russia.
Mane is considered the key figure in the squad, which he joined after playing for Liverpool against Real Madrid in the Champions League final.
Liverpool crushed Manchester City 3-0 in the Champions League quarter-final first leg on Wednesday.
Champions League quarter-finals: Early blitz hands Liverpool commanding lead 3-0 over Manchester City
However, a perfect night for Liverpool was marred when Salah limped off with an injury early in the second half.
Sadio Mane says Liverpool can beat any team in the world as Jurgen Klopp's men chase the Premier League runners-up spot.
Mane says his Champions League hat-trick has given him a confidence boost as Liverpool seek to climb to second in the EPL.
Liverpool put one foot in the Champions League quarterfinals with a 5-0 away rout of Porto in the first leg of their last-16 match.
Mohamed Salah, Sadio Mane and Michael Olunga starred on a great weekend for Africans across the major European leagues.
Salah and Aubameyang were named on Monday among the three finalists for the African Player of the Year award.