Wimbledon should have been happening right now but was called off for the first time since 1945 because of the COVID-19 outbreak.
Williams and Ohanian had their first daughter in September 2017. She had won the Australian Open earlier in the year when she was roughly eight to nine weeks pregnant.
The US was given an early advantage after Australian Open champion Sofia Kenin rolled with a dominant 6-2, 6-2 win over Anastasija Sevastova in the opening match.
Coach Patrick Mouratoglou also conceded that Serena Williams is running out of time.
38-year-old Serena Williams powered past the Russian teenager Anastasia Potapova 6-0, 6-3 in 58 minutes.
Serena Williams can make history at the Australian Open as she pursues a 24th Grand Slam singles title.
Serena Williams has been on the cusp of history since 2017, but after returning from giving birth has suffered straight-sets defeats in four Slam finals.
Serena ends three-year title drought, gives Auckland Classic prize money to Australia bushfire relief
The 38-year-old tempered celebrations as she donated her US$43,000 winners cheque to the Australian bushfire relief fund and described how the tragedy had affected her deeply.
Halep captured her second career major with a 6-2, 6-2 victory, adding a maiden Wimbledon to her 2018 Roland Garros triumph.
The 36-year-old Serena Williams stated that she is trying to take things lightly and is taking out some moments to relax.
At a time when so many of her peers have long since retired, Serena is still pushing her body through the gruelling hours of training and practice.
Serena Williams has dominated women's tennis for more than a decade, winning 23 Grand Slams including seven titles at the All England Club.
Seeded 25 this year and with a world ranking of 181, Williams insists she will be the underdog against Kerber on Saturday despite boasting a 6-2 career lead over the 30-year-old left-hander.
In only her fourth tournament since the birth of her daughter Olympia in September, the 23-time Grand Slam champion is closing in on her first major title as a mother.
Williams avoided a major upset on Tuesday as the former world number one battled back to beat unseeded Camila Giorgi 3-6, 6-3, 6-4 in a Centre Court thriller.