Manchester City have been hard hit by the virus with 11 players and staff testing positive in recent weeks.
Aguero will come back at his best, won't be bogged down by injury, says Manchester City gaffer Guardiola
Manchester City are currently at the 11th spot in the Premier League 2020-21 standings and the side will next take on Fulham later on Saturday.
City have scored just 10 goals in eight top-flight matches this season, though their strike record in Europe is more impressive, with nine goals in their three games.
City boss Pep Guardiola revealed he was waiting to discover the full extent of the injury to the club's all-time record scorer.
Aguero, who returned from a four-month spell out with injury in Saturday's 1-0 win over Arsenal, has entered the last 12 months of his existing deal.
WATCH | Manchester City player Aguero touches lineswoman by shoulder, Guardiola defends him amid controversy
The lineswoman was then seen swatting Aguero's arm away from her.
Manager Pep Guardiola feels that Aguero will take one or two months to regain match fitness.
The 32-year-old Aguero is currently going through his recovery week and Guardiola has said that he would have a full squad for the match against Madrid.
The match also saw a controversial moment when a message saying 'White Lives Matter Burnley' was flown over the Etihad Stadium.
The Premier League has been suspended since March 13 due to the pandemic, as are most other major sports competitions around the world.
Coronavirus outbreak: Manchester City striker Sergio Aguero teaching British kids to count in Spanish
Aguero says it's a tough time for children at the moment, and also for parents trying to keep them focused on their education from home.
Guardiola was back on the touchline in the Welsh capital and the champions were back in the old routine after their shock midweek defeat at home by Lyon in the Champions League.
Champions City edged ahead of Chelsea, who travel to West Ham on Sunday, into second, two points behind the leaders, as they bounced back from a shock Champions League defeat to Lyon.
Mbappe, 19, struck twice within minutes in the second half to put France 4-2 ahead and although Sergio Aguero gave the French a late scare with a goal in injury-time they held on.
Argentina must beat Nigeria in Saint Petersburg if they are to avoid a premature exit following a disastrous 3-0 defeat by Croatia.