The Indian women under Mithali Raj and Harmanpreet Kaur have now lost four successive white-ball series with two at home against South Africa.
Sydney Sixers are close to formalising a deal with Shafali and left-arm spinner Radha Yadav. Smriti Mandhana, Harmanpreet Kaur, Deepti Sharma, Jemimah Rodrigues could also be in demand.
Barring Mithali Raj's remarkable consistency in ODIs, the Indian batting was a disappointment and it is something that the team would want to correct in the three T20s.
Chasing 220, Mithali, who became the highest run-getter across all formats in women's cricket on Saturday, anchored India's chase with an unbeaten 75 off 86 balls.
Madhana, a stylish left-hander, and young Shafali Verma had forged a solid 167-run stand with their half-centuries in India's response to the massive England first innings total of 396/9 declared.
Mandhana will next be seen in India's upcoming tour of England. India Women are set to lock horns against England Women in one-off Test, 3 ODIs and 3 T20Is.
The Hundred: Harmanpreet Kaur to play for Manchester Originals, Smriti Mandhana to represent Southern Brave
The Hundred is a 100-ball cricket competition that will see prominent players featuring in the tournament later this year in the English summer.
It is understood that the BCCI even thought of hosting these matches in Ahmedabad alongside the IPL play-offs.
Shafali Verma along with Smriti Mandhana continued the carnage in the first six overs and as a result, the hosts' score read 71/0 after the end of six overs.
For India, opener Smriti Mandhana will lead the side as Harmanpreet Kaur suffered a hip-flexor injury.
The hosts face an uphill battle after they lost T20I captain Harmanpreet Kaur to the hip injury she sustained during the fifth ODI.
Harmanpreet suffered a hip-flexor injury while batting in the fifth ODI against South Africa on Wednesday.
After losing the series-opener by eight wickets, Indian women crushed South Africa by nine wickets to draw parity.
India haven't played a T20 International in over a year. They last played on March 8, 2020 when they lost to Australia in the T20 World Cup final.
Smriti Mandhana scored an unbeaten half-century after Jhulan Goswami returned a four-wicket haul as India women thumped South Africa women by nine wickets in the second ODI.