The Brazil international scored his 12th goal of the season with a fine curling effort and provided an assist for compatriot Roberto Firmino.
Swansea City's decision to sack manager Paul Clement reflected the mounting anxiety in the Premier League's lower reaches as the frenetic festive period begins.
He took over at Swansea in January, replacing Bob Bradley, with the club bottom of the Premier League and tipped as odds-on favourites for relegation.
City can hit a new high by beating Swansea to break the record they currently share with Arsenal for consecutive Premier League wins.
Conte's side play Newcastle United in the 1230 GMT kick-off at Stamford Bridge on Saturday, having beaten Swansea City 1-0 on Wednesday.
Portuguese Sanches joined Swansea City on a season-long loan move from Bayern Munich, the English Premier League club announced Thursday.