Blinken, 58, served as deputy secretary of state and deputy national security adviser during the Obama administration and has close ties with Biden.
Pompeo's predecessor Rex Tillerson, who advocated widespread cuts to the department, was unceremoniously fired by Trump in March.
He replaces Rex Tillerson, who was fired by President Donald Trump in March.
Tillerson was also thought to have made a major concession to China when he publicly repeated Beijing's rhetoric about the Sino-US relationship during his first trip to the country.
President Donald Trump's sacking of Secretary of State Rex Tillerson could sound the death knell for the Iran nuclear deal and further strain US ties with key European allies.
After arriving from Ukraine, Tillerson met with his Turkish counterpart Mevlut Cavusoglu yesterday and later held talks with President Recep Tayyip Erdogan, officials on both sides said.