The 34-year-old Kompany left City to join Anderlecht, his first professional club, in a player-manager role in May last year.
The former City captain is under contract as player-manager of Anderlecht until 2022, having left the Etihad Stadium last year following a trophy-laden 11-year spell.
Sterling has scored 20 goals for club and country this season, which includes a 13-minute hat-trick against Watford.
If Kompany is unfit, coach Roberto Martinez will drop him in favour of Laurent Ciman, who plays for Los Angeles in the MLS.
It was an impressive statement of intent from Guardiola's men after a shock FA Cup defeat to lowly Wigan last week ended their bid for an unprecedented quadruple.
Kompany suffered his third injury of the season when he limped off with a calf problem during the match against Newcastle.
The centre-back, who has a long history of calf problems, sustained a calf injury after completing the 90 minutes of Belgium's 4-0 victory over Gibraltar in World Cup qualifying last week.