In their last match, Liverpool edged out Wolves to record a 2-1 win to consolidate their pole position in the standings.
Manchester United defender Harry Maguire fails to measure up as Virgil van Dijk leads Liverpool title charge
Liverpool, by contrast, are again the meanest backline in the division thanks in large part to a run of eight consecutive clean sheets.
Liverpool registered a 2-0 win over Salzburg in the Champions League on Tuesday. Naby Keita and Mohamed Salah scored one goal each in the second half.
Cristiano Ronaldo's sister destroys Virgil van Dijk on Instagram, asks Dutchman to win trophies before talking
Cristiano Ronaldo was a three-time champion in the country where you have been playing for years and you still haven't got your hands on the trophy, Katia Aveiro told the Dutchman.
On Monday, Messi won his sixth Ballon d'Or and went ahead of Ronaldo, who has won the award five times.
The Dutch captain came second to the Argentina forward despite playing a huge role as Liverpool won the Champions League last season, overcoming Messi's Barcelona in the semi-final.
Liverpool top the Premier League points table with 31 points while Manchester City holds the fourth position with 25 points.
Messi and Ronaldo's 10-year grip on the individual award organized by France Football magazine was broken by Luka Modric last December.
The European champions are in pole position to end a 30-year wait to win a league title, but Van Dijk believes the pressure is still on Manchester City to win the league for a third straight year.
Jurgen Klopp's side briefly extended their advantage to eight points after beating Sheffield United 1-0 in the early kick-off on Saturday but City beat Everton to reduce the gap.
Messi claimed the prize, rebranded in 2016, for the first time, beating van Dijk and Juventus star Cristiano Ronaldo.
Van Dijk had earlier triumphed over Messi and Ronaldo to win the UEFA Best Men's Player of the year.
Van Dijk, Ronaldo and Messi are the three men's finalists for The Best Player award, with the winner to be announced on Monday in a star-studded ceremony in Milan's famous opera house La Scala.
The Dutch international denied Cristiano Ronaldo and Lionel Messi for the European title last week and the same trio are in the running for the FIFA accolade to be announced in Milan on September 23.
Van Dijk has been so instrumental in Liverpool's improvement from the side that finished 25 points adrift of City last season.