South Africa will next play Sri Lanka in their third Group 1 match on October 30, while West Indies will take on Bangladesh a day earlier.
Lewis (56) and Lendl Simmons (16) got West Indies off to a flier.
In a big upset for South Africa, Quinton de Kock is not be available for the match due to personal reasons, making way for Reeza Hendricks.
T20 World Cup: West Indies' title defence begins on disastrous note, England hammer them by 6 wickets
Jos Buttler and skipper Eoin Morgan saw England through and ensured there was no more drama in the contest.
Invited to bat, West Indies were all out for 55 in 14.2 overs in their T20 World Cup Super 12 Group 1 match against England.
England skipper Eoin Morgan won the toss and elected to bowl against defending champions West Indies in their Super 12 Group 1 match.
The West Indies will need the likes of Evin Lewis, Lendl Simmons, Shimron Hetmyer and Nicholas Pooran to fire to make a good start and win at least three group matches to qualify for the semifinals.
Heading into the showpiece, Gayle is just 97 runs short of becoming the highest run scorer in T20 World Cup.
Ambrose, a known critic of the 'Universe Boss' said that Gayle shouldn't be 'an automatic choice' in the West Indies playing eleven for the T20 World Cup.
Pooran made 85 runs at an average of 7.72 playing for Punjab Kings in IPL 2021, a stark contrast to his record in 2020, in which he averaged 35.30 with a strike rate of 169.71 across 14 innings.
He went wicket-less against Rajasthan Royals and Sunrisers Hyderabad and in an earlier match against RCB but took three wickets in the team's two-wicket defeat to Chennai Super Kings.
Head Coach Phil Simmons will be looking to make it back-to-back titles as he was the mastermind behind the title to success in 2016.
ICC charged Marlon Samuels for breaching four counts of the anti-corruption code during a T10 league, including failure to disclose hospitality benefits that could bring disrepute to the sport.
India will play New Zealand, West Indies, Sri Lanka and South Africa in the home season which starts with T20Is against New Zealand and ends with T20Is against South Africa.
Roston Chase was also included in the squad, earning a T20I call-up for the first time, mostly due to his form in the Caribbean Premier League.