The grim milestone comes as countries around the globe battle rising infections, despite the gradual rollout of vaccination campaigns.
It took 307 days, since the first COVID-19 case was recorded in Mumbai on March 11 last year, to cross the grim milestone of 3 lakh cases.
Global infections have soared past 91 million, and the spikes have forced governments around the world to reimpose restrictions such as unpopular and economically painful lockdown.
The total number of cases stood at 2,90,640 while recoveries were at 2,84,611.
The number of people who have recuperated from the disease surged to 1,01,29,111 pushing the national COVID-19 recovery rate to 96.51 per cent.
The death toll increased to 1,51,327 with 167 daily new fatalities, the data updated at 8 am showed.
With the addition of fresh infections, the overall cases in the country reached 1,04,50,284 including 2,23,335 active cases.
Dr Hans Kluge, head of WHO's Europe office, said the agency's procedures had been "overlooked," as he sought to explain WHO's decision to pull the report from its website.
India's COVID-19 tally had crossed the 20-lakh mark on August 7, 30 lakh on August 23, 40 lakh on September 5 and 50 lakh on September 16.
Three more returnees have tested positive for the new UK variant of the coronavirus, taking the total number of UK returnees testing positive for the UK strain in Tamil Nadu to four.
The death toll now stands at 1,551.
The 251 new cases were detected in 23 of the 30 districts of the state with 148 reported from different quarantine centres, while 103 are local contact cases.
The COVID-19 active caseload remained below 3 lakh for the ninth consecutive day.
Ludhiana reported 42 new cases, Jalandhar 36 and Mohali 31, among fresh cases detected in the state.
The agency says 17,163 people with active infections remain in quarantine and 330 of them are in serious or critical condition.