Kylian Mbappe had ended up missing a penalty against Switzerland and the striker has dubbed it as the low point of his career.
Among those missing were four players who also played with Spain in the Tokyo Olympics - Pedri González, Pau Torres, Mikel Oyarzabal and Dani Olmo.
City open their Premier League defence away to Tottenham on Sunday with Foden also set to miss clashes against Norwich and Arsenal.
Maguire was a major doubt for the European Championship, but Gareth Southgate waited on him even though the former Leicester defender was not fit until the third group game.
This might be a match between teams who have almost forgotten what it feels like to lose -Spain has only one defeat in its last 29 games — but Italy looks to have the edge, at both ends of the field.
Without Ramos, or any other Real Madrid player for the first time in Spain's history at a major tournament, the Madrid press cried foul, claiming La Furia Roja would lack leadership.
The Portuguese became the first team to score two own-goals in one game at the continental tournament, giving the Germans a 4-2 victory on Saturday.