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Deadly cytomegalovirus infection reported in five Covid patients at Delhi's Sir Ganga Ram Hospital

The hospital in a statement on Tuesday claimed this is the first report from India of cases of cytomegalovirus (CMV) related rectal bleeding in Covid-19 immunocompetent patients.

Published: 30th June 2021 03:52 AM  |   Last Updated: 30th June 2021 08:37 AM   |  A+A-

Sir Ganga Ram Hospital in Delhi

Sir Ganga Ram Hospital in Delhi. (File Photo | Anil Shakya/EPS)

By Express News Service

NEW DELHI:  Five cases of cytomegalovirus (CMV) infection, causing rectal bleeding in patients who had earlier tested positive for Covid-19, have been reported at Sir Ganga Ram Hospital in Delhi.

The hospital in a statement on Tuesday claimed this is the first report from India of cases of cytomegalovirus (CMV) related rectal bleeding in Covid-19 immunocompetent patients.

According to the hospital, the affected patients complained of blood in stool, pain or intestinal obstruction. One of them died because of severe Covid infection and “massive bleeding”, while another patient required surgery.

“During the second wave of the pandemic in April-May, we have seen five cases of CMV infection in otherwise immunocompetent patients with Covid-19. These patients presented themselves with pain in the abdomen and blood in stool. The symptoms were reported around 20 to 30 days after Covid-19 diagnosis,” said Prof Anil Arora, chairman, Institute of Liver Gastroenterology and Pancreaticobiliary Sciences, Sir Ganga Ram Hospital.

Out of five patients in the age group ranging 30-70 years, four had lower gastrointestinal bleeding; that is blood in stool, and another patient complained of intestinal obstruction.

Two of them had massive bleeding, one requiring emergency surgery.

The other patient succumbed due to massive bleeding and severe chest disease. Other three patients were successfully treated with antiviral therapy.

Dr Sunila Jain, senior consultant pathologist from the facility, added that cytomegalovirus colitis was confirmed by PCR testing for CMV and tissue biopsy. 

“In case of infection, early diagnosis and effective antiviral therapy can save lives,” said Dr Praveen Sharma, senior consultant, Gastroenterology Department, Sir Ganga Ram Hospital.

These patients reported at the facility 20-30 days after the diagnosis of Covid, doctors at the hospital said.

Until now, it affected only the immunocompromised patients, post-transplant, cancer, AIDS etc.

According to Professor Anil Arora, chairman, Institute of Liver Gastroenterology and Pancreaticobiliary Sciences at the hospital, "During the second wave of the pandemic, in April-May, we have seen five cases of the CMV infection in otherwise immunocompetent patients with COVID-19.

" These patients presented with pain in abdomen and bleeding during stool discharge.

None of them had other predisposing immunosuppressed states accounting for this viral infection, he said.

The Covid infection itself and the medicines used for its treatment (like steroids) do suppress the immunity of patients and make them susceptible for uncommon infections with varied presentations, the hospital said in a statement.

"One such opportunistic infection is from CMV Cytomegaloirus and it exists in 80 to 90 per cent of the Indian population in asymptomatic form as our immunity is strong enough to make it clinically asymptomatic.

Clinical presentation with symptoms secondary to CMV is usually seen in patients whose immunity is compromised," it said.

But in these five cases, all patients presented with a "low lymphocyte count (6-10 per cent as against a normal of 20-40 per cent)", indicating Covid-induced suppression of immunity predisposing them to symptomatic reactivation of the CMV infection, doctors said.

These patients in the age group of 30-70 are from Delhi-NCR and four of them had presented with a lower gastrointestinal bleed, which is bleeding in stools, and one of them presented with intestinal obstruction, the statement said.

"Two of them had massive bleeding, one requiring an emergency life-saving surgery in the form of the removal of the right side of the colon, while one of them succumbed due to massive bleeding and severe COVID-19 chest disease," the hospital said.

The three other patients were successfully treated with antiviral therapy with ganciclovir, Arora said.

"Cytomegalovirus colitis was confirmed by PCR testing for CMV viremia and tissue biopsy from the large intestine, which showed intranuclear inclusion bodies which was further confirmed to be due to the CMV infection by the specific immunohistochemistry stains," said Dr Sunila Jain, a senior consultant pathologist at the hospital.

In such cases, a high index of suspicion and timely intervention in the form of an early diagnosis and effective antiviral therapy can save many a precious lives, opined Dr Praveen Sharma, senior consultant at the hospital's gastroenterology department.

Meanwhile, the Moolchand hospital said in a statement that new cases and the flaring up of old anal fissure and piles in many COVID-19 patients or those in the recovery phase have been reported in the last few months.

A post-Covid patient, a 55-year-old man, had come as an OPD patient to the surgical department of the hospital with a four-day history of bleeding in the rectum, along with painful defecation for the last 12 days, the hospital authorities said.

The patient said he had been drinking four-five glasses of "kadah" a day for the last three months, doctors said.

He was treated surgically and discharged in 24 hours.

Subsequently, his symptoms were found to have completely disappeared, the statement said.

According to Dr Sachin Ambekar, consultant, department of laparoscopic and minimal access surgery at the hospital, "Since March, I have regularly been seeing three to five OPD patients a day coming with symptoms of anal fissures and piles. On probing, patients have been found to be following home remedy treatments sent on WhatsApp groups."

They have apparently been overdosing themselves with vitamin D, vitamin C as also herbal and "kadah" preparations and which have, in the long term, flared up the symptoms of an existing fissure or piles.

Moreover, even new cases of acute anal fissures have been observed, he said.

Ambekar said "overzealous use of 'kadah', a herbal home-made concoction, is a leading cause of piles and anal fissures in COVID-19 and post-COVID-19 patients".

These hot concoctions over a period of time dry up the mucous lining or membrane of the stomach and intestines, causing severe constipation and thus, leading to anal fissures.

Earlier, anal fissure with piles were termed as lifestyle diseases.

In the present scenario, it is a "self-styled disease" caused due to the stress and fear of contracting COVID-19, the doctor said.

Ambekar has "surgically treated roughly 350 patients of anal fissure and piles related to post COVID-19 home remedy therapies" since March, the hospital claimed, adding that many of them required surgical intervention like laser therapy, MIPH, while some were managed conservatively.

(With PTI Inputs)

Cytomegalovirus (CMV) is a common virus

  • Once infected, body retains the virus for life.

  • Most people don’t know they have CMV  because it rarely causes problems  in healthy people.

  • During pregnancy or weakened  immunity, CMV is cause for concern.

  • CMV spreads from person to person through body fluids.

  • The primary symptoms of CMV infections are mild such as sore throat, muscle aches, fatigue, swollen glands and fever.

  • Careful hygiene is the best prevention against CMV.

  • Digestive system problems, including inflammation of the colon (colitis), esophagus (esophagitis)

  • and liver (hepatitis).

  • Vision loss, due to inflammation of the light-sensing layer of the eye (retinitis).

  • Nervous system problems, including brain inflammation (encephalitis).



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