Blindness (2008): The 2008 film, an adaptation of the 1995 novel of the same name by Portuguese author Jose Saramago, was about a society suffering an epidemic of blindness. Directed by Fernando Meirelles, the film had Julianne Moore and Mark Ruffalo fronting its cast. The film was special to Ruffalo, who learned in 2001 that he had a brain tumor called an acoustic neuroma. In 'Blindness,' he played a character who is made helpless by an illness and whose experiences were 'magnified, amplified and retooled' variations of his own, heraldextra.com had reported.