Ayatollah Ali Khamenei said the US adopted a policy of "maximum pressure" on Iran because it believes it cannot bring the Islamic republic to its knees through other means.
The Trump administration plan centers on a USD 50 billion Palestinian investment and infrastructure proposal, but avoids core political issues that are key to resolving the dispute.
The sanctions followed Iran's downing last week of a US surveillance drone, worth over USD 100 million, over the Strait of Hormuz, sharply escalating the crisis.
But the Islamic republic's founder and revolutionary leader Ayatollah Ruhollah Khomeini died in 1989, and the country has since been led by Ayatollah Ali Khamenei.
According to a media report, Abe's planned meeting with influential Khamenei will be the first such talks between a Japanese premier and Tehran's supreme leader.
Wednesday's attack, which targeted a busload of Revolutionary Guards in the volatile southeastern province of Sistan-Baluchistan, was one of the deadliest on Iranian security forces in years.
Khamenei was having a dig at US officials who had predicted there would be regime change in Iran by the end of 2018.
Tens of thousands gathered in cities across Iran on Wednesday in a massive show of support for the regime after days of deadly unrest, state television showed.
In a dramatic shift from 2009, protesters now are chanting slogans against Khamenei and rejecting the ruling system.
A total of 21 people have died in five days of unrest across the country which began as protests over the economy before quickly turning against the Islamic regime as a whole.
Demonstrations are spreading across Iran and turning increasingly violent, but analysts say a lack of leadership and political support mean they may struggle to maintain momentum.
The supreme leader of Iran said in a statement on state television, that the 'enemies' of the country of joined hands to create problems for the regime.
Iran's Supreme Leader Ayatollah Ali Khamenei on Tuesday said that violence in Myanmar against the Rohingya Muslims marks the "death of Nobel Peace Prize".