Sindhu, who had defeated Indonesia's Choirunnisa in the opening round, lost 19-21, 18-21 to Jindapol in a match that lasted for around 50 minutes.
In a men's singles quarterfinal match earlier in the day, Sameer Verma too was shown the door after he suffered a 10-21 12-21 loss to second seed Shi Yuqi of China.
Besides the female duo, Sameer Verma too continued his impressive run by progressing to the men's singles quarterfinals.
Something interesting happened at the KD Jadhav Indoor Hall on Friday. The first Indians in action were the women’s doubles pair of Aparna Balan and KP Shruthi.
Srikanth, who had clinched four titles in 2017, lost nine quarterfinals and two semifinals while reaching the finals only once at the Commonwealth Games in the last 15 months.
In women's doubles, Ashwini Ponnappa and N Sikki Reddy and Meghana Jakkampudi and Poorvisha S Ram will be in fray, while Pranaav Jerry Chopra and Sikki will be the best hope in mixed event.
Nehwal will now face the winner of the quarterfinal match between Chen Xiaoxin and He Bingjiao.
Commonwealth Games bronze medallist pair of Ashwini Ponnappa and N Sikki Reddy also bowed out of the competition, losing 14-21 14-21 to Thailand's Jongkolphan Kititharakul and Rawinda Prajongjai
Despite the pressure of a minimum number of tournaments, picking the competitions they will take part in will help shuttlers cope with their workload.
Fifth seed Srikanth, ranked 9th, saw off France's Lucas Corvee 21-12 21-16 in 35 minutes to set up a clash with Indonesia's Tommy Sugiarto.
World No 64 Subhankar took 45 minutes to upstage the current world No 12, who has five World Championship titles and two Olympic gold medals in his kitty.
Ashwini and Sikki caused a massive upset in the recent Denmark Open ousting seventh seed Lee So Hee and Shin Seung Chan of South Korea to make the quarterfinals.
Shuttlers Chirag Shetty and Satwiksairaj Reddy want to crack top 15 and win a super 300 title next year
Chirag and Satwik emerged as India's best-ranked men's doubles pair this year, where they claimed a maiden silver medal at Commonwealth Games, clinched the Hyderabad Open Super 100 title
Third seed Sindhu lost 17-21 21-16 18-21 to Zhang in another tough opening encounter that lasted 56 minutes.
Athletes in the SL3 category generally have impairment in one or both lower limbs and poor walking or running balance.