City boss Guardiola was forced to deploy Brazilian midfielder Fernandinho at centre-back after losing Aymeric Laporte and John Stones to recent injuries.
The reigning English Premier League champions suffered the upset of the season, so far, as Teemu Pukki scored one goal and assisted another at Carrow Road.
Laporte damaged cartilage and the lateral meniscus in his right knee after a clash with Brighton's Adam Webster in City's 4-0 win on August 31.
The result was also a personal triumph for United’s £80 million ($99 million) defender Harry Maguire, signed from Leicester last month and jeered and taunted throughout the game.
Tottenham and Chelsea bounced back to form with comprehensive wins over Crystal Palace and Wolves respectively, while Manchester United held out for a much-needed three points.
Manchester United hoped the Spanish international would sign a new deal before the season began, but are still waiting for De Gea to put pen to paper.
Pogba twisted his ankle in the 1-1 draw at Southampton two weeks ago and did not play for France in their two matches during the international break.
Kompany will miss playing in his City testimonial on Wednesday due to a hamstring injury, but was in attendance as the club also named a road at their training base after the centre-back.
The 31-year-old Richards might have labelled Ronaldo as the best this year, but he did not take Ronaldo's name when he was asked about who his toughest opponent was.
England were 23-1 at stumps, 474 runs behind, with Rory Burns 15 not out and nightwatchman Craig Overton unbeaten on three.
This was the third time this Ashes he had reached three figures following scores of 144 and 142 in the first Test at Edgbaston, with his lowest total of the series the 92 he made at Lord's.
The former captain missed England's dramatic one-wicket win in the third Test at Headingley after being felled by a bouncer from paceman Jofra Archer in the drawn second match of the series at Lord's.
The English champions didn't give an exact timeframe for Laporte's absence, but the nature of the injury means he is unlikely to play again until the new year.
Stuart Broad took two early wickets, including David Warner for a duck.
Sanchez failed to live up to the expectations United had when signing him from Arsenal on a four-and-a-half year contract in January 2018, scoring just five times in 45 appearances for United.