- Tag results for Milos Raonic
Del Potro is looking for his 22nd career and second straight ATP title in a row after winning earlier this month in Acapulco.
The 27-year-old Raonic defeated American Sam Querrey 7-5, 2-6, 6-3 to pick up just his fourth match win of the season and is seeking to capture his ninth career ATP Tour title.
World number five Alexander Zverev slumped to a shock defeat to unheralded Joao Sousa in his opening match at Indian Wells.
Raonic got his 2018 off to a roaring start with a 6-1, 7-5 rout of Taro Daniel in the first round of the Delray Beach Open on Tuesday.
Milos Raonic was knocked out of the Australian Open by Lukas Lacko in his earliest exit at Grand Slam for seven years.
The 36-year-old Swiss bidding for a record 20th Grand Slam title, has a first-round encounter with the 51st-ranked Bedene.
The former world number one is making a tilt at a record seventh Melbourne Park crown, but has some serious rust to shake off if he is to make an impression.
Raonic, who won the Brisbane title in 2016 and reached the Wimbledon final that year, struggled to find the rhythm against the 18-year-old Minaur.
Raonic defeated Federer in the 2016 Brisbane final, will be playing in the Australian Open warmup tournament for the fourth time.
The former world number three, playing his first tournament since undergoing wrist surgery, lasted just eight minutes of his clash with Sugita.
Raonic looked sharp on his return from wrist surgery as he battered Troicki 6-3, 6-4 in the first round of Japan Open.
The world number 11 said he had a procedure on Wednesday to remove portions of bone that had been causing him discomfort for weeks.
World number 10 Milos Raonic of Canada withdrew from the ATP Cincinnati Masters on Tuesday with a left wrist injury.
The seven-time champion reached the Wimbledon semi-finals for the 12th time, with a 6-4, 6-2, 7-6 (4) win over Canadian Raonic, and will next face Tomas Berdych.
Milos Raonic reached the Wimbledon quarter-finals on Monday with a 4-6, 7-5, 4-6, 7-5, 6-1 win over Alexander Zverev.