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The coalition has targeted the defence ministry in the past, leaving it heavily damaged, but the fresh strikes come as tensions ratchet up between Saudi Arabia and its rival Iran.
A suspected airstrike by the Saudi-led coalition fighting Shiite rebels in Yemen killed at least 26 people and wounded nine others in the country's north.
The sanctions' targets include Abu Sulayman al-Adani, identified as the overall leader of the growing Islamic State operation in Yemen.
Yemeni eyewitnesses say Saudi-led airstrikes have hit at least three houses in the capital, Sanaa, killing at least 14 civilians, including women and children.
The victims were refugee who died in an air strike on the city of Taiz in southern Yemen.
An airstrike by the Saudi-led coalition battling Yemeni rebels struck a vehicle packed with fleeing civilians on Tuesday, killing at least 11 people.
Qatif, an eastern province in Sunni-ruled Saudi Arabia, has been hit by a string of attacks over the past week, some of them deadly.
Arms depots and military vehicles belonging to the Houthi militias were completely destroyed in the Saudi-led bombing in Taiz's western area.
The air raid targeted an area held by the Huthi rebels, said the source who confirmed that a vehicle had been struck.
Around 20 fighters and renegade troops were also wounded.
The United States said it would review its support for the Saudi-led coalition in Yemen.