Tottenham have already made history for the club by getting this far -- they last reached the semi-finals of the European Cup in 1962 before being beaten by Eusebio's Benfica.
Spurs won last week in their first match at their new home, beating Crystal Palace 2-0 to move back into third in the Premier League after a disappointing run of results.
From a clinical performance from Kane to Lloris leading from the front.
Pochettino pointed to Rennes, who postponed a French league game at the weekend to prepare for Thursday's Europa League tie at home to Arsenal.
After losing 3-0 to Spurs at Wembley in the first leg of the last 16, Dortmund face a monumental task against Mauricio Pochettino's team at Signal Iduna Park in the return fixture.
Dortmund have to overturn a 3-0 defeat at Wembley and are hoping to call on Reus' services in the second leg.
After watching replays of his heated exchange, the 46-year-old Argentinian said he could offer no defence.
The Spurs boss was involved in a lengthy and heated exchange with referee Mike Dean after the loss against Burnley.
Tottenham have kept in touch with Manchester City and Liverpool with three successive wins.
Reus went off after drilling in a superb free-kick, his 17th goal in all competitions this season, in Tuesday's shock German Cup home defeat by Werder Bremen.
City trail Klopp's men by four points, with Tottenham two points further back, but both of Liverpool's rivals are still involved in four competitions.
Blues supporters have been under the spotlight in recent weeks after a number of high-profile incidents, including a derogatory chant about Spurs supporters that featured alleged anti-Semitic language
Harry Kane ended a five-game goal drought from the penalty spot and Erik Lamela doubled Tottenham's lead before Anthony Knockaert pulled a late goal back for Brighton.
Goalkeeper and captain Lloris has a thigh injury while midfielders Alli and Sissoko have hamstring problems that saw them miss Saturday's 2-1 Premier League home loss to Liverpool.
Nearly every able-bodied South Korean man is required to enrol by age 28 in the military, for a minimum of 21 months.