Inhaled Nitric Oxide can kill SARS-COV-2, reveals study

As the global search for an effective remedy against Covid continues, this strategy to use iNO as a therapeutic measure could be a successful, rapid and affordable game-changer in that direction.
Coronavirus (Photo | AP)
Coronavirus (Photo | AP)

KOCHI: Any findings and research giving breakthroughs for tackling Covid-19 would be a relief for the health sector.

A recent study involving doctors and scientists from Amrita Hospital, Kochi and School of Biotechnology, Amrita Vishwa Vidyapeetham found that inhaled Nitric Oxide (iNO) is virucidal and has the capability of killing the SARS-COV-2 virus, apart from preventing its effective attachment to human host cells.

The well-known gas Nitric Oxide (NO) has been used worldwide for the treatment of medical conditions like Blue Baby Syndrome and other ailments including heart or lung transplants.

In the feasibility trial conducted at Amrita Hospital, Covid-19 patients who received the iNO therapy recovered faster with lesser complications and zero mortality rates compared to patients who received the standard Covid-19 treatment without iNO.

“Our interest in looking at Nitric Oxide as a treatment option for Covid-19 stemmed from an early study conducted by a Swedish group which had suggested that the gas can prove effective in curbing the SARS-COV-2 virus, as it induces biochemical changes which directly affect the spike protein of the virus. This protein is the main culprit in interacting with our body’s receptors and immune system and creating havoc,” said Bipin Nair, Dean, Life Sciences at Amrita School of Biotechnology

The team of experts at Amrita Hospital headed by Dr. Aveek Jayant, Dr. Dipu T S, and Dr. Merlin Moni, decided to conduct this trial on a small group of Covid patients admitted at Amrita Hospital. Out of the 25 patients selected for the study, 14 were given iNO along with standard treatment for Covid-19, while 11 patients were in the Control standard treatment group. According to the doctors, the patients treated with iNO showed a significant drop in their viral load

“This approach to repurposing Nitric Oxide has the potential to be an effective preventative, especially in light of the highly infectious nature of the Omicron variant prevalent today,” say the experts who conducted the study.

As the global search for an effective remedy against Covid continues, this strategy to use Nitric Oxide as a therapeutic measure has the scope to be a successful, rapid and affordable game-changer in the fight against the pandemic.

It is conceivable that healthcare workers, who are constantly exposed to the coronavirus, could also use this as a prophylactic while treating infected patients,” said Dr. Geetha Kumar, Amrita School of Biotechnology.

The study by Amrita Hospital successfully demonstrates the putative role of repurposed inhaled Nitric Oxide in hypoxemic Covid-19 patients. The expert panel associated with the study now calls for an extended validation to take this treatment process to the next level.

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The New Indian Express