Andres Iniesta has claimed that Barcelona must make Manchester City "suffer" in the Nou Camp tonight (Wednesday), with Manuel Pellegrini's team facing Champions League elimination against the La Liga leaders.
City need to score at least two goals to keep their hopes alive after losing 2-1 in the round-of-16 first leg.
Having lost at Burnley on Saturday - a defeat which leaves City six points behind Premier League leaders Chelsea - the Champions League offers them their only realistic prospect of silverware this season.
However, Iniesta claimed that Barcelona are eager to exploit their first-leg advantage by making the 90 minutes as difficult possible for City.
"We will have to play in a comprehensive manner so that they [City] have to suffer and follow the ball," Iniesta said. "We must find our superior skills as much as possible. If we don't do this, City can achieve their objective, but we must control the situation as much as possible.
"City are a very sound team, with high quality players in all positions and it is a difficult opponent for us to overcome. They are very dangerous because of their players. In just one minute, they can turn the result upside down. So at all levels, we must be 200 per cent concentrated. We cannot make the mistake, and will not make the mistake, that we have guarantees because of the first-leg scoreline. We need to get the ball, make them run and do all possible to be in the next round."
After City, Barcelona tackle Real Madrid on Sunday - a sequence which could define the club's season. While a draw in both games would strengthen Barcelona's prospects of success in the Champions League and La Liga, Iniesta insisted that they would not be playing for stalemates.
"You go out to win, especially when playing at home," Iniesta said. "The best thing is to win and we will see how the match goes. But we know with a draw or win, we will qualify for the next round, so I would sign up for a draw now because it would mean we are in the next round.
"We have to go out to win the match, play as we usually play, and make the most of our opportunities. It's obvious you don't need to risk as much after a good first-leg result, but it is very difficult to predict what will happen."
City have received five red cards in the Champions League in the past year, including three in three games against Barcelona - one of which has left Gael Clichy suspended tonight.
Pellegrini admitted that City's hopes rested on avoiding further disciplinary issues.
"The most important thing is to play with 11 players," he said.
"Last year we played 40 minutes with one player less, then lost Pablo Zabaleta for 15 minutes in the second game. In the last game we played 20 minutes without a player. It is difficult to play against Barcelona with 11 players and almost impossible with 10, so I hope to see 11 v 11 and the best team will qualify."