Djokovic defeated a battling but exhausted Kevin Anderson 6-2, 6-2, 7-6 (7/3) to add the 2018 title to his wins in 2011, 2014 and 2015.
He also took his Grand Slam total to 13 after a year which had seen him struggle with form and confidence, sending his world ranking to its lowest in over a decade.
"The grass tasted really well. I had a double portion this year to treat myself," said the 31-year-old.
The sight of Djokovic snacking on the Centre Court grass has become a Wimbledon tradition since the Serb first did it after beating Rafael Nadal in 2011 final.