The 25-year-old Australian will play former world number one Karolina Pliskova of the Czech Republic in Saturday's final.
The 25-year-old Australian will play either former world number one Karolina Pliskova of the Czech Republic or Belarusian second seed Aryna Sabalenka in Saturday's final.
The stage is set for the women's Wimbledon semi-finals on Thursday with three of the contenders new to the experience.
The 33-year-old German former world number one fell out of love with the game for a spell but is back in the form she showed in 2018.
Gauff will face former Wimbledon champion Angelique Kerber on Monday.
Angelique Kerber, the 2018 Wimbledon champion, is into her first WTA final since 2019 having come out on top in the evening semi-final.
The 26th-seeded Kerber was beaten 6-2, 6-4 by Anhelina Kalinina, a qualifier from Ukraine ranked 139th making her tournament debut.
While Serena was frustrated by the surprise setback, she took heart from her run to the final in just the fourth tournament of her comeback following daughter Olympia's birth in September.
Williams had hoped to equal Margaret Court's record of 24 Grand Slam singles titles by winning her first major prize since becoming a mother in September.
Kerber, who had won 11 career titles compared to Serena Williams's 72, has not been afraid to make tough decisions.
Serena Williams has dominated women's tennis for more than a decade, winning 23 Grand Slams including seven titles at the All England Club.
Seeded 25 this year and with a world ranking of 181, Williams insists she will be the underdog against Kerber on Saturday despite boasting a 6-2 career lead over the 30-year-old left-hander.
In only her fourth tournament since the birth of her daughter Olympia in September, the 23-time Grand Slam champion is closing in on her first major title as a mother.
It will be world number 10 Kerber's first Grand Slam final since she won the second of her two major titles at the 2016 US Open.
American Sloane Stephens had cause for a double celebration after beating Germany's Angelique Kerber 6-1, 6-2 to reach the WTA Miami Open semi-finals.