St Kitts and Nevis Patriots reached their highest powerplay score of this year's Hero CPL, Gayle and Lewis bringing up 68-0 after the first six overs.
Guyana Amazon Warriors confirmed their place in the 2021 CPL semi-finals with a second consecutive win over the Jamaica Tallawahs.
The Barbados Royals lost Kyle Mayers in the third over but rebuilt with Charles and Hope looking confident at the crease.
The Amazon Warriors won the toss and elected to bat first and captain Nicholas Pooran led the way with a brutal 75 not out to set the Tallawahs 170 to win.
The Patriots bowled brilliantly and then backed that up with a dominant batting display that saw them knock off the victory target with 32 balls to spare in Saturday's match.
Du Plessis batted though the innings as he recorded his highest T20 score of 120 not out off just 60 balls after Saint Lucia Kings were put in to bat.
Andre Russell bludgeoned his way to a record 14-ball unbeaten 50 as Jamaica Tallawahs hammered St Lucia Kings by 120 runs.
Trinbago Knight Riders, the most successful team in the CPL, will seek to add more glory to their name and another trophy to their cabinet.
Carlos Brathwaite had travelled from Manchester to Basseterre ahead of the CPL after leading Manchester Originals in the ECB's inaugural edition of the Hundred.
TKR head coach Brendon McCullum will miss the upcoming season of the Caribbean Premier League due to personal reasons.
Three players from Afghanistan have been named in the rejigged squads for the upcoming Caribbean Premier League starting from August 26.
The comment came after Smith played his debut match at CPL, where he helped Tridents register a 30-run victory over Shoaib Malik-led Guyana Amazon Warriors.