Set 486 runs to win at the Adelaide Oval, England was 142-6 after the opening session on the fifth day of the second Ashes Test.
Allrounder Ben Stokes will stand in as captain as the tourists seek to avoid defeat in Adelaide and go two-nil down in the five-Test series.
It will be Smith’s first appearance as captain since the Cape Town, South Africa ball-tampering scandal in 2018 which cost him the captaincy and a subsequent two-year leadership ban.
Vice-captain Steve Smith will captain the team in Cummins’ absence. Michael Neser comes into the playing XI to replace Cummins and make his test debut, with Travis Head vice-captain.
Australia are a perfect eight from eight as they go into the pink-ball test against England beginning Thursday at the Adelaide Oval.
Speaking at the Adelaide Oval on Tuesday, Travis Head, man-of-the-match in Australia's win at the Gabba last week, said he is keen to continue with his attacking style of play in the second Test.