Cristiano Ronaldo will hone in on Morocco on Wednesday after his stunning hat-trick in Portugal's World Cup opener.
First choice keeper de Gea was badly at fault for Portugal's second goal of the game when he let a long-range shot from Portugal captain Cristiano Ronaldo squirm from his grasp.
Lopetegui has given his backing to Spain at the World Cup, despite being fired as coach just 48 hours before their opening game at the tournament in Russia.
Hierro and Ramos posed together, smiling for the cameras, at a press conference inside the Fisht Olympic Stadium in Sochi.
Untested Spanish coach Fernando Hierro hopes to repeat Zinedine Zidane's coaching success in FIFA World Cup 2018
Hierro is taking on a major coaching job without any significant previous experience, just as Zidane did at Real Madrid.
Lopetegui never lost in 20 games as Spain boss, but even in a flawless qualifying campaign on the field, the Madrid-Barca rivalry.
The 50-year-old Hierro's only real coaching experience came when he was in charge of second division Spanish outfit Oviedo for one season.