ICC Women's T20I Rankings: India's Shafali Verma consolidates position at the top, check full list here
Shafali, who had regained the top position among batters last week, is now on 776 rating points and enjoys a 35-point lead over Australia's Beth Mooney.
This is the first time that the Indian women's team has lost a T20 series against the South Africans.
Chasing the target, Lizelle Lee smashed a 45-ball 70 studded with 11 fours and a six, while Laura Wolvaardt slammed an unbeaten 39-ball 53 as South Africa romped home in the last ball.
Harleen Deol's (52) confident maiden international fifty was the only silver lining for an otherwise lacklustre display by the Indians.
The hosts face an uphill battle after they lost T20I captain Harmanpreet Kaur to the hip injury she sustained during the fifth ODI.
India skipper Mithali Raj top-scored with an unbeaten 79 off 104 balls while Harmanpreet Kaur retired hurt after scoring 30 before the hosts were all out for 188.
Chasing a competitive 249, Lee starred for the visitors with her breathtaking knock that came off 131 balls and had 16 fours and two hits over the fence.
On Tuesday she claimed 4 for 42 to set up India's nine-wicket win over South Africa in the second ODI, helping the side level the five-match series 1-1.
Asked to bat, India never got the momentum it needed and could only manage 177 for nine despite sedate fifty from skipper Mithali Raj and a quick-fire 40 off 41 balls from Harmanpreet Kaur Lee.
Looking at giving youngsters an opportunity; we will see Shafali very soon, says India skipper Mithali Raj
The women's cricket team would return to international cricket action after almost one year as they will lock horns in the five-match ODI series against South Africa.
Shafali Verma has played 19 T20 Internationals so far, scoring 487 runs at an impressive strike rate of 146.24.
Harmanpreet Kaur said that India is not feeling any sort of rustiness as they prepare to return to international cricket after a gap of one year.
Indian pacer Shikha Pandey's omission from the ODI and T20 teams for the South Africa series created quite a flutter.
When Karnataka medium-pacer Monica Patel learned about her inclusion in India’s women squad for the South Africa series, she had tears of joy.
The series, consisting of five ODIs and three T20Is, is due to begin on March 7 at Lucknow.