With 24 of the 54 random samples testing positive, officials believe that community spread has started and quarantine, treatment, and testing centres will be started in the zone.
The minister said testing, treatment and quarantining will be strengthened inside the "clusters" in order to stop the spread of the virus beyond a particular area.
Despite asking the public to be on vigil and repeating time and again that we are close to community spread, the state government is yet to confirm it.
On Friday, out of 791 fresh COVID-19 cases, 532 were through local transmission. The situation is especially alarming in Thiruvananthapuram where 246 tested positive for the virus.